Well this is my 3rd pregnancy, the 2nd with my husband. my last pregnancy when they did my blood work they found anti-s. no one knows for sure what it is i just had to be monitored closely. well this current pregnancy i still have the s but now i have anti-e too. my husband is getting blood work done . but im curiouse if anyone has ever heard of either of them and if they know anything about it. i have found that  the e is compared to the rh factor. If anyone can help me i would appreciate it.

Hmm Rachelle, that is strange. I have no clue what those are. This is my 2nd pregnancy. Umm have you tried googling it or even asking your doctor about it? 

Yes i have looked all over the internet for both the only thing i have found is the anti-e causes anemia. today i found out my husband is the carrier of the anti-e. My dr is reffering me to a blood doctor and such so i hope in time i will have more answers. But im comfortable knowing that as long as my titers are watched every month and they dont budge my baby will be fine like my last. Thank you

Rachelle

I have the anti-S antibody.  Yes, there is a difference between anti-s and anti-S but they are from the same antibody 'family'.  If you try to google either one of these, you are not going to find a whole lot, but from what I did find...  These antibodies are dealt with in a similar manner as the rh factor.  I found a few medical journal articles on the anti-s and anti-S antibody and IF the mother's blood and the baby's blood touch, then there is a slight risk for 'hemolytic anemia' meaning your baby could be jaundice or in the extreme case ( 0.1%) of the time need a blood transfusion.  With that being said, your anti-s has been identified and precautions can be taken.  The case studies and effects mentioned were cases where the anti-s and anti-S were identified AFTER the baby was born.

I have an ultrasound and genetic counseling sheduled for Thursday, August 14th, 2008.  I will reply following this appointment and let you know if I have any new information.

Btw, there could be an upside to your scenario!  I received information from a legitimate plasma donation company who are looking for people to donate plasma containing these antibodies.  The anti-s and anti-S antibodies only effect about 0.01% of the population, but if someone with this antibody need blood it is in limit supply.  Therefore, plasma donation is needed to for blood donation supply and also for medical research.  Depending on your titre level after pregnancy and if you meet the requirements for plasma donation, you could be paid about 10 times more than the national average rate for regular blood plasma donation ($50 for ordinary blood). 

 

hi..your pregnancy needs a due care.......your baby can be in real danger of HEAMOLYTIC DISEASE OF NEW BORN caused by anti bodies from mother which cross placenta  and if the baby carries a correponsing anigen, the anti bodies attach to the antigen on the rbcs finaly damaging the cells of the baby  causing heamolysis of rbcs...in result the bilirubin levels rise and baby undergoes  anemia...anti e belongs to rh system   and e anti gen is very common if your baby crries the e antigen  it can be harmful..you can know it by doing  RH. phenotyping of your husband to rule out if the baby can be e pos..S is part of MNS system....antis might have produced in your circulation   either due to transfusion of blood ,or due to cross over of some cells from your previous baby....this anti body also crosses  placenta and causes  HDN.....your gynea should remain in close consultation with immunoheamatologist...tohelp you.....you may need   amniocentisis  

any take care...

I have 3 children with my last 2 I found out that I had anti S everything turned out fine, however was just wondering if anyone happened to know if this only affects you if your pregnant or does it stay with you for life?  thanks

Well I am now 33 weeks and my titers have gone up on the antiE. I have goten some answers but should have more on Monday. What answers i do have are that the E cause anemia and jaundice in the baby and in severe cases congestive heart failure but only if the E was not detected during the pregnancy. I see the specialist monday and the safest thing for the baby is to be born at 36 weeks. I will have a ultrasound to look at his heart and blood vessels to see if his heart is damaged and if his blood flow is good. Up until now my titers have not budged so they think he should be ok. And if I find out anymore info on this i will definately post it for anyone who might have this problem. The S im not sure about but will definately ask the specialist on monday so i can post answers on that.

Thank you everyone who has tried to help i appreciate it alot.

Rachelle 

Hi Rachelle ,

I am pregnant with my 3rd child ,i too have anti-E and anti-S , I will tell you what i know and what i have gone through in hope you dont have the same happen to you ,

my second pregnancy i recieved conf that i had antibodies -E and Jka they decided not to re do blood titres until 26 weeks ! they then done them every two weeks as the titres where going up ,i spoke with the consultant who advised they didnt know what to expect and that everything would be fine and basically i was to stop being so worried the worst would be jaundice .

I had my bloods done repeatedly and at 38 weeks i recieved a call saying 'come in now we need to get the baby out ' I had all ready been in to hospital a few days before as i didnt feel baby was moving alot -again they made me feel as if i was worrying too much .

I went into hopsital ,they induced me 4 hours later my baby boy was out smaller than im used to . He ws born not breathing and they hit the alarm , He spent the next 2 weeks in intensive care where he recieved excessive light phototherapy -even so much they had tinfoil around him to make the light bounce ,He had blood tests done every hour -All his veins in his hands and feet collapsed ,I wasnt allowed to hold him or feed him at all , He recieved blood wash's (transfusions) .

Basically -S and -E can cause Hdn hemolytic problems with your baby , Be prepared. I would suggest you speak to your consultant and sk to be induced before the levels get too high why chance anything ,

Basically the antibodies work in this way , You have them now as apart of your blood system -like your litte army men they fight infections and keep you healthy , When your baby is in the womb and takes it's fathers blood group and is big enough for some of the baby's blood to pass through the  cord your body detects a foreign blood group and tries to attack and neutralise your babys blood leading to your baby getting anemia and tiredness and basically very ill .

I am in my 3rd pregnancy and ive been advised if the titres get too high then they will give my baby a blood transfusion in the womb ! Or induce . Either was be prepared

My son is now 2 and you would never know he hd ever been ill .-Good luck x

Hi Rachelle, I'm now in my 3rd pregnancy, and my first Anti-e titre level was below 1 which I was happy to see cause I didn't know what to expect after having gone through an anti-e pregnancy already. Anti-e was not an issue with the first, but that's because the blood doesn't mix until after you give birth? I don't remember the explanation I received, but my anti-e only showed up in the second pregnancy.

I was given blood tests every month in the beginning, and towards the end of the pregnancy, I basically had to do the blood tests every 2 weeks, and also an ultrasound every 2 weeks. My levels got to a 4. My daughter was born fine and without any problems (not even jaundiced). I was told if my levels got to a 32, then I would have to go to another hospital which specialised in high-risk births. I was told the worst case scenario was a blood transfusion (which would be done in utero) if I was too early to be induced. If I was far enough in the pregnancy, then they would induce me. I remember my titres were 1 up until the last month (or maybe the second last month) which is when it jumped to a 4... but then it stayed there. I'm hoping to experience the same with this pregnancy so I don't have to worry about it.

Naturesmagick, I am just curious... do you know what your titre levels were in your last pregnancy? I wonder if having anti-S as well as anti-e causes more risk? Also, did your levels start to increase at the end of your pregnancy? In my experience, my levels never rose until towards the end. I'm a week away from my second trimester, and my last titre reading was well below 1. Hopefully that's a good sign!

I also had anti-s.  Basically,  you were born without the antigen to s.  Most people were born with that particular antigen, which elicits an immune response, IE an antibody.  At some point you were exposed to the s (and e)antigens, which caused your body to begin to manufacture antibodies against it (them) thus creating a greater risk for your baby.  If your baby were to have the s or e antigen, your body would fight against it.  It would desroy the baby's red blood cells, much in the same way that an Rh negative mother would attack an Rh positive baby.

This is my second pregnancy this year.  The first ended in a miscarriage for "unknown reasons."  It was during my first pregnancy, that I received an "urgent call" from my Nurse Practioner who notified me that I had "Anti-E factor" and that I'm "going to need close monitoring during the pregnancy and I'll need to see a high risk pregnancy doctor from then on."  When I asked her to explain what Anti-E factor was and what it meant to my pregnancy, she only replied that I am going to have to be monitored throughout the pregnancy to make sure my titre number stayed below 32.  That really didn't mean much to me, since she didn't explain what it meant to have this factor and why is it so important to monitor; what does a no. >32 mean to the me or the baby? I was very nervous and scared.  I ended up doing my own research online. Unfortunately, there wasn't a lot out there in layman terms about Anti E factor relative to treatment, monitoring, etc.   My first pregancy lasted only 9 weeks.  I was concerned if it was related to the "anti E factor."  My NP and OBGYN doc. denied my miscarriage was related to the Anti E factor, since my titer level at that time was only 16. 

Now I'm on my second pregnancy, 11 weeks in now. I'm having to do my titer levels monthly. So far it is at 16 again. What I don't understand is my high risk pregnancy doctor doesn't think me having Anti E factor is a problem. But isn't that why I'm seeing a high risk doctor.  I'm not getting the informattion I need to prepare myself mentally or physically. Is there someone out there that can help me understand Anti E factor and what that means to my pregnancy?